Gene information
Official symbol MMP9
Official full name matrix metallopeptidase 9
Gene type protein-coding gene
Chromosome20q13.12
Previous symbolCLG4B
Gene familyM10 matrix metallopeptidases
Resources
Entrez Gene 4318
HGNC HGNC:7176
Ensembl ENSG00000100985
Vega OTTHUMG00000033044
UCSC uc002xqz.3
GO terms: 131 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001706 endoderm formation GO Biological Processes -7.82381493 14 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002573 myeloid leukocyte differentiation GO Biological Processes -7.83519790 12 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004222 metalloendopeptidase activity GO Molecular Functions -10.6700212 15 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007492 endoderm development GO Biological Processes -8.07123392 17 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007566 embryo implantation GO Biological Processes -9.99023740 10 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0010822 positive regulation of mitochondrion organization GO Biological Processes -5.15923818 8 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030099 myeloid cell differentiation GO Biological Processes -6.71806250 15 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030225 macrophage differentiation GO Biological Processes -6.19476810 6 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0030857 negative regulation of epithelial cell differentiation GO Biological Processes -6.09984616 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0032092 positive regulation of protein binding GO Biological Processes -4.19203093 7 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034614 cellular response to reactive oxygen species GO Biological Processes -9.93259803 24 More
GO:0034644 cellular response to UV GO Biological Processes -5.54644403 9 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0035987 endodermal cell differentiation GO Biological Processes -8.15231722 13 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -5.11653120 8 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043271 negative regulation of ion transport GO Biological Processes -19.3914052 40 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043388 positive regulation of DNA binding GO Biological Processes -12.0675836 19 More
GO:0043393 regulation of protein binding GO Biological Processes -7.80142307 15 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO Biological Processes -3.18614571 7 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0046686 response to cadmium ion GO Biological Processes -6.32553812 8 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051099 positive regulation of binding GO Biological Processes -11.1715489 31 More
GO:0051101 regulation of DNA binding GO Biological Processes -9.69427751 24 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051547 regulation of keratinocyte migration GO Biological Processes -3.13889786 3 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070141 response to UV-A GO Biological Processes -7.87763977 6 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0071478 cellular response to radiation GO Biological Processes -4.2266687 10 More
GO:0071482 cellular response to light stimulus GO Biological Processes -4.67282705 9 More
GO:0071492 cellular response to UV-A GO Biological Processes -8.67610245 6 More
GO:0090199 regulation of release of cytochrome c from mitochondria GO Biological Processes -6.79373102 8 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:1900120 regulation of receptor binding GO Biological Processes -6.64459385 6 More
GO:1900122 positive regulation of receptor binding GO Biological Processes -4.05291246 3 More
GO:1901184 regulation of ERBB signaling pathway GO Biological Processes -3.96203474 12 More
GO:1901186 positive regulation of ERBB signaling pathway GO Biological Processes -3.03839152 7 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904645 response to amyloid-beta GO Biological Processes -11.2505232 12 More
GO:1904705 regulation of vascular associated smooth muscle cell proliferation GO Biological Processes -22.4951686 19 More
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation GO Biological Processes -15.2818318 12 More
GO:1904724 tertiary granule lumen GO Cellular Components -12.6232675 13 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2000117 negative regulation of cysteine-type endopeptidase activity GO Biological Processes -4.79670615 8 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO Biological Processes -4.22212529 4 More
KEGG pathways: 14 records
KEGG Description Category LogP Number of genes Detail
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04915 Estrogen signaling pathway KEGG Pathway -2.87451539 7 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa05161 Hepatitis B KEGG Pathway -5.78517620 12 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05219 Bladder cancer KEGG Pathway -8.60591296 9 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
andecaliximab antibodyinhibitor ChemblInteractionsTTD view
bevacizumab CIViC 26921265 view
carboxylated glucosamine DTC 16616490 view
celecoxib PharmGKB 22336956 view
curcumin TTD view
curcumin pyrazole DTC 19128977 view
demethylwedelolactone DTC 22926226 view
incyclinide TdgClinicalTrial view
marimastat inhibitor TdgClinicalTrialTEND 172341801276366111752352 view
prinomastat vaccine TALC view
s-3304 vaccine TALC view
tozuleristide TTD view
Related studies: 55 records
Molecular factor Omics type Application Objective MI type Reference
MMP9 transcriptomics cerebral infarction[prognosis (bad)] acute myocardial infarction Zhou L et al. Eur Rev Med Pharmacol Sci. 2019
NM_004994.3:c.[-1562C>T;836A>G] genomics myocardial infarction[diagnosis] myocardial infarction Horne BD et al. Am Heart J. 2007
matrix metalloproteinase-9 proteomics myocardial injury[prognosis (bad)] acute ST elevation myocardial infarction Kaden JJ et al. Cardiology. 2003
matrix metalloproteinase-9 proteomics infarct-related artery[other] acute ST elevation myocardial infarction Funayama H et al. Circ J. 2004
matrix metalloproteinase-9 proteomics myocardial infarction[diagnosis] myocardial infarction Renko J et al. Scand J Clin Lab Invest. 2004
matrix metalloproteinase-9 proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Tziakas DN et al. Thromb Res. 2006
matrix metalloproteinase-9 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Circ J. 2005 et al. Circ J. 2005
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Fukuda D et al. Am J Cardiol. 2006
matrix metalloproteinase-9 proteomics congestive heart failure[prognosis (bad)] acute myocardial infarction Wagner DR et al. J Card Fail. 2006
matrix metalloproteinase-9 proteomics ventricular septal rupture[prognosis (bad)] acute myocardial infarction Kameda K et al. Circ J. 2006
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kameda K et al. Circ J. 2006
matrix metalloproteinase-9 proteomics left ventricular remodeling[prognosis (bad)] myocardial infarction Webb CS et al. Circulation. 2006
matrix metalloproteinase-9 proteomics myocardial infarction[diagnosis] myocardial infarction Webb CS et al. Circulation. 2006
matrix metalloproteinase-9 proteomics statin[treatment (pharmacotherapy)] acute myocardial infarction Yasuda S et al. Clin Sci (Lond). 2007
matrix metalloproteinase-9 proteomics cardiogenic shock[prognosis (bad)] ST elevation myocardial infarction Dominguez-Rodriguez A et al. Atherosclerosis. 2008
matrix metalloproteinase-9 proteomics death[prognosis (bad)] ST elevation myocardial infarction Dominguez-Rodriguez A et al. Atherosclerosis. 2008
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Hlatky MA et al. Am Heart J. 2007
matrix metalloproteinase-9 proteomics post infarct cardiac rupture[prognosis (bad)] myocardial infarction van den Borne SW et al. Cardiovasc Pathol. 2009
matrix metalloproteinase-9 proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
matrix metalloproteinase-9 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tan J et al. Clin Cardiol. 2008
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dai F et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
matrix metalloproteinase-9 proteomics myocardial infarction[diagnosis] myocardial infarction Jefferis BJ et al. Atherosclerosis. 2010
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Nie R et al. Arch Med Res. 2009
matrix metalloproteinase-9 proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Miyazaki S et al. Circ J. 2010
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Buduneli E et al. J Periodontol. 2011
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Park HJ et al. Circ J. 2011
matrix metalloproteinase-9 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Tan J et al. Yonsei Med J. 2012
matrix metalloproteinase-9 proteomics poor predictor left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Urbano-Moral JA et al. Heart. 2012
matrix metalloproteinase-9 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Kampourides N et al. Am J Cardiol. 2012
matrix metalloproteinase-9 proteomics coronary revascularization[prognosis (bad)] acute myocardial infarction Wang KF et al. Coron Artery Dis. 2013
matrix metalloproteinase-9 proteomics medium predictor major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Guo JL et al. Zhonghua Yi Xue Za Zhi. 2012
matrix metalloproteinase-9 proteomics left ventricular remodeling[prognosis (bad)] acute anterior myocardial infarction Cogni AL et al. Arq Bras Cardiol. 2013
matrix metalloproteinase-9 proteomics medium predictor cardiovascular death[prognosis (bad)] acute myocardial infarction Berezin AE et al. Asian Cardiovasc Thorac Ann. 2013
matrix metalloproteinase-9 proteomics good predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Zhang Y et al. Cytokine. 2015
matrix metalloproteinase-9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Li Y. Technol Health Care. 2015
matrix metalloproteinase-9 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Nishiguchi T et al. Arterioscler Thromb Vasc Biol. 2016
matrix metalloproteinase-9 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Setianto BY et al. Cardiol Res. 2012
matrix metalloproteinase-9 proteomics poor predictor death[prognosis (bad)] acute myocardial infarction Zhu JJ et al. Oncotarget. 2017
matrix metalloproteinase-9 proteomics atorvastatin[treatment (pharmacotherapy)] acute anterior myocardial infarction Liu ZJ et al. Chin Med Sci J. 2018
matrix metalloproteinase-9 proteomics cerebral infarction[prognosis (bad)] acute myocardial infarction Zhou L et al. Eur Rev Med Pharmacol Sci. 2019
matrix metalloproteinase-9 proteomics poor predictor cardiovascular death[prognosis (bad)] ST elevation myocardial infarction Somuncu MU et al. Rev Port Cardiol. 2020
matrix metalloproteinase-9 proteomics medium predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Chen Z et al. IUBMB Life. 2020
NM_004994.3:c.-1562C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koh YS et al. Int J Cardiol. 2008
NM_004994.3:c.-1562C>T genomics myocardial infarction[diagnosis] myocardial infarction Wang L et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011
NM_004994.3:c.-1562C>T genomics myocardial infarction[diagnosis] myocardial infarction Wang L et al. Clin Appl Thromb Hemost. 2012
NM_004994.3:c.836A>G genomics myocardial infarction[diagnosis] myocardial infarction Wang L et al. Clin Appl Thromb Hemost. 2012
NM_004994.3:c.-1562C>T genomics myocardial infarction[diagnosis] myocardial infarction Rodriguez-Perez JM et al. Genet Mol Res. 2016
NM_004994.3:c.-1562C>T genomics myocardial infarction[diagnosis] myocardial infarction Daraei A et al. Genet Test Mol Biomarkers. 2017
NM_004994.3:c.-1562C>T genomics death[prognosis (bad)] acute myocardial infarction El-Aziz TAA et al. Int J Cardiol. 2017
NM_004994.3:c.-1562C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction El-Aziz TAA et al. Int J Cardiol. 2017
NM_004994.3:c.-1562C>T genomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Pavkova Goldbergova M et al. J Appl Genet. 2017
NM_004994.3:c.-1562C>T genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Setianto BY et al. Cardiol Res. 2012
NM_004994.3:c.-1562C>T genomics myocardial infarction[diagnosis] myocardial infarction Sheikhvatan M et al. J Clin Lab Anal. 2018
NM_004994.3:c.836A>G genomics myocardial infarction[diagnosis] myocardial infarction Sheikhvatan M et al. J Clin Lab Anal. 2018
NM_004994.3:c.836A>G genomics left ventricular dilation[prognosis (bad)] acute myocardial infarction Sokolova NA et al. Kardiologiia. 2018
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